POSTDOC POSITION IN DETECTION AND QUANTIFICATION OF RNAS AND THEIR MODIFICATIONS FROM NANOPORE DIRECT RNA SEQUENCING DATA (M)

Commitment %26amp; contract.
collaboration contractLocation.
MILAN -Center for Genomic Science (CGS) https://www.
it.
t/it/cgs-semmWHO WE AREAt IIT we work enthusiastically to develop human-centered Science and Technology to tackle some of the most pressing societal challenges of our times and transfer these technologies to the production system and society.
Our Genoa headquarter is strictly inter-connected with our 11 centers around Italy and two outer-stations based in the US for a truly interdisciplinary experience.
OUR TEAM You will be working in a multicultural and multi-disciplinary group at the Center for Genomic Science (CGS), one of the IIT's centers, which is located within a larger research campus, the IFOM-IEO CAMPUS in Milan (http://www.
fom-ieo-campus.
t).
The Center hosts scientists with different backgrounds collaborating, each with their own expertise, to carry out common research.
CGS has its own lab space and infrastructure and also benefits from state-of-the art technological platforms in molecular/cellular biology and genomics located at the IFOM-IEO CAMPUS.
The Center is part of the RNA initiative (iRNA@IIT), a scientific action promoted by the IIT and aimed at generating ground-breaking interdisciplinary knowledge in the fields of RNA biology, RNA technologies and RNA-based therapeutics.
he GENOMIC SCIENCE Research Unit is coordinated byDr.
Francesco Nicassio, who has extensive experience in Genomics and Non-Coding RNA biology.
The lab is engaged in a number of projects in areas of cancer genomics, development and stem cells focusing on the role of noncoding RNA transcripts.
Notably, our research activity is based on the integration of Experimental models with Computational methodologies, pointing out the reciprocal regulation of coding and non-coding RNAs.
ttps://www.
it.
t/it/web/guest/people-details/-/people/francesco-nicassiohttps://www.
it.
t/it/web/genomic-scienceWe are seeking a senior Scientist - post-doctoral level - to join the Computational RNA biology team.
This team develops algorithms, software and data-analysis strategies to study the function, evolution and regulation of RNA molecules.
We have a particular focus on the application and development of methods based on Nanopore direct RNA-Sequencing, a new technology that for the first time allows to sequence full-length, native RNA molecules without the need for retrotranscription or amplification.
By designing and creating dedicated tools we can leverage the potential of this technology to dissect the transcriptional output of complex loci, quantify isoform expression and determine non genomically encoded transcript features, such as epitranscriptional modifications or polyA tail length.
epresentative publications can be found here:%26middot; RNA modifications detection by comparative Nanopore direct RNA sequencing - Nat Commun.
doi.
rg//smiddot; Nanopore ReCappable sequencing maps SARS-CoV-prime; capping sites and provides new insights into the structure of sgRNAs - Nucleic Acid Res.
doi.
rg//nar/gkacmiddot; Benchmarking of computational methods for m6A profiling with Nanopore direct RNA sequencing - Brief Bioinform.
doi.
/bib/bbae001 PMID:%26middot; Unveiling the role of PUS7-mediated pseudouridylation in host protein interactions specific for the SARS-CoV-2 RNA genome - Mol Ther Nucleic Acids.
doi.
rg//j.
mtn.
PMID.
ithin the team, your main responsibilities will be:%26middot; Applying existing tools and pipeline for the analysis of Nanopore direct RNA Sequencing data, with a particular focus on methodologies for the detection of RNA modifications;%26middot; Developing new computational methods and analytical strategies to characterize the role of RNA modifications in a broad range of biological contexts, such as regulation of long non-coding RNAs, biogenesis and maturation of microRNAs and mechanisms of cancer progression and chemo-resistance;%26middot; Coordinating and co-supervising junior members of the lab, participate to meetings and be involved in disseminating results from the Research Line Genomic Science headed by Dr.
Francesco Nicassio.
EQUIREMENTS%26middot; PhD level degree in a natural science discipline, such as Biology, Biotechnology, Mathematics, Physics, or similar%26middot; Documented experience in genomics, bioinformatics and scientific programming in R or Python%26middot; Good data analysis skills and a basic understanding of statistics%26middot; Ability to properly report and organize data%26middot; Good command in spoken and written English%26middot; Team-working ability%26middot; High motivation to learn%26middot; Experience on Nanopore sequencingEXTRA AWESOME%26middot; Good level of knowledge on the biology of RNA modifications%26middot; Experience with bioinformatics workflow management tools such as Nextflow or SnakemakeGood communication skills %26middot; Strong problem solving attitude%26middot; Spirit of innovation and creativity%26middot; Ability to work in a challenging and international environment%26middot; Ability to work independently and collaboratively in a highly interdisciplinary environmentCOMPENSATION %26amp; BENEFITS%26middot; Competitive salary package for international standards%26middot; Private health care coverage %26middot; Wide range of staff discounts%26middot; Candidates from abroad or Italian citizens who permanently work abroad and meet specific requirements, may be entitled to a deduction from taxable income of up to 90% from 6 to 13 years.
HAT'S IN FOR YOU?%26middot; A dynamic, lively, and international team of people, working together to bring research to a new level!%26middot; An equal, inclusive and multicultural environment ready to welcome you with open arms.
Discrimination is a big NO for us!%26middot; We like contamination and encourage you to mingle and discover what other people are up to in our labs! %26middot; If paperwork is not your piece of cake, we got you! There's a specialized team working to help you with that, especially during your relocation! %26middot; If you are a startupper or a business-minded person, you will find some exceptionally gifted professionals ready to nurture and guide your attitude and aspirations.%26middot; If you want your work to have a real impact, in IIT you will find an innovative and stimulating culture that drives our mission to contribute to the improvement and well-being of society!%26middot; We stick to our values! Integrity, courage, societal responsibility and inclusivity are the values we believe in! They define us and our actions in our everyday life.
They guide us to accomplish IIT mission!If you feel this tickles your appetite for change, do not hesitate and apply!Please submit your application using the online form and including a detailed CV, cover letter (outlining motivation, experience and qualifications) and contact details of at least 2 references.
pplication's deadline.
May 28th Please note that this position is pending budget approval.
e inform you that the information you provide will be used solely for the purposes of evaluating and selecting professional profiles in order to meet the requirements of Istituto Italiano di Tecnologia.
our data will be processed by Istituto Italiano di Tecnologia, based in Genoa, Via Morego 30, acting as Data Controller, in compliance with the rules on protection of personal data, including those related to data security.
lease also note that, pursuant to articles 15 et.
seq.
of European Regulation no.
(General Data Protection Regulation), you may exercise your rights at any time by contacting the Data Protection Officer (phone Tel.
+ ).